THE FREQUENCY OF METABOLIC SYNDROME IN PATIENTS WITH ISCHEMIC HEART DISEASE (Synopsis)

Synopsis on THE FREQUENCY OF METABOLIC SYNDROME IN PATIENTS WITH ISCHEMIC HEART DISEASE

Introduction / Background
Introduction/ Background The metabolic syndrome is a cluster of clinical characteristics thought to be associated with enhanced coronary risk.”1” The metabolic syndrome is more prevalent with the use of the recently defined National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria and is associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components.”2” In 1988, Reaven “3”noted that several risk factors (e.g. dyslipidemia, hypertension, hyperglycemia) commonly cluster together. This clustering he called Syndrome X, and he recognized it as a multiplex risk factor for cardiovascular disease CVD. Individuals with metabolic syndrome are at increased risk for coronary heart disease CHD.”4” Insulin resistance (IR) as being a central pathophysiological process behind the metabolic syndrome “5.6” presence of metabolic syndrome increases the risk of coronary artery disease CAD by 7.3 times in male and 10.2 times in female patients “9” ATP III identified CVD as the primary clinical outcome of the metabolic syndrome According to ATP III, underlying risk factors for CVD are obesity (especially abdominal obesity), physical inactivity, and atherogenic diet ”7,8” the major risk factors are cigarette smoking, hypertension, elevated LDL cholesterol, low HDL cholesterol, family history of premature coronary heart disease CAD and aging; and the emerging risk factors include elevated triglycerides, small LDL particles, insulin resistance, glucose intolerance, pro inflammatory state, and pro thrombotic state
Objectives
OBJECTIVE
To find the frequency/ pattern of metabolic syndrome in patients with IHD and its impact on in hospital complication and outcomes
Material and Methods
Hypothesis
Study Design : Descriptive Study
Sample Size : 100 Consecutive patients who are 30 years and above and admitted with diagnosis of first episode of Ischemic heart disease (IHD) i.e. acute Myocardial infarction, (STEMI, NSTEMI ) acute coronary syndrome (ACS) will be included
Sampling Method : A baseline data from the history, risk factors, physical examination, and laboratory will be collect
Duration of Study : Three months
Inclusion Criteria
patients who are 30 years and above and admitted with diagnosis of first episode of Ischemic heart disease (IHD) i.e. acute Myocardial infarction, (STEMI, NSTEMI ) acute coronary syndrome (ACS) will be included
Exclusion Criteria
Does not give informed consent
H/O Stoke
Known pt of renal failure
Chronic obstructive pulmonary disease
Data Collection Procedure
Subjects will be assessed for the 5 component conditions of the metabolic syndrome: insulin resistance or fasting blood sugar, abdominal obesity based on waist circumference, hyper triglyceridemia, low HDL cholesterol (HDL-C), and hypertension, metabolic syndrome will be defined as at least 3 of the 5 conditions
Fasting blood samples will be drawn for the measurement of glucose total cholesterol, HDL cholesterol, and triglyceride concentrations in the first 24 hour of admission
The study variables will be collected on a Performa
Statistical Methods
All the data collected will be entered on SPSS software version 12.0. Frequency variable will be generated. Cross tabulation of the variable of interest will be compiled, where appropriate. Chi-square test and t- test will be applied for qualitative and quantitative analysis’s respectively to see the relationship between various variables. Cut off point for significance will be taken on p< 0.05 at 95% confidence interval. Power point soft ware will be used to present data in graphical form and Microsoft word will be used for final completion of research report








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