Role of intravenous immunoglobulins for prevention and treatment of neonatal sepsis in preterms
|Introduction / Background
The benefit of passive immunization by prophylactic administration of intravenous immune globulin (IVIG) for prevention of bacterial infections has been established for patients with primary agammaglobulinemia and with symptomatic human immunodeficiency virus infection. Routine administration of IVIG for other immunocompromised hosts has not consistently been shown to clearly decrease the incidence of bacterial infections. IVIG appears to have a role in sepsis as it neutralizes bacterial toxins, enhances opsonisation and chemotaxis and modulates cytokine release. Several studies were canducted to. demonstrate the efficacy of IVIG in the prevention and treatment of neonatal sepsis. Exogenous immune globulin given at birth to premature low birth weight newborns may be beneficial for prevention of early-onset sepsis after peripartum transmission of maternal vaginal flora in the setting of low maternal antibody levels and for late-onset and late, late-onset (occurring after 30 days from birth) nosocomial infections.
The objective of this study is to determine whether therapy with intravenous immunoglobulin G (IVIG) would decrease mortality in neonatal sepsis.
|Material and Methods|
|Similar Preliminary Studies
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